反应详情

The title compound was obtained following procedure and work up described for Intermediate 47 step 2 but starting from 3-{[(2-Methoxy-ethyl)-methyl-amino]-methyl}-benzonitrile obtained in step 1 (6.4 g, 31.3 mmol) to give the title compound as yellow viscous liquid (6.9 g, 93%). 1H NMR (DMSO-d6, 400 MHz) δ 9.57 (s, 1H), 7.59 (s, 1H), 7.50-7.53 (m, 1H), 7.28-7.29 (m, 2H), 5.75 (s, 2H), 3.48 (s, 2H), 3.41-3.44 (m, 2H), 3.21 (s, 3H), 2.48-2.52 (m, 2H), 2.13 (s, 3H). LC/MS (Method A): 238.1 (M+H)+.