反应详情

The title compound was prepared following procedure described for example 4, step 1, but starting from Intermediate 49 (995.01 mg; 3.50 mmol) and 5,6-dichloronicotinic acid (806.4 mg; 4.2 mmol). The reaction mixture was evaporated. The crude product was dissolved in EtOAc and washed with NH4Cl sat, NaHCO3 sat, brine and dried over MgSO4. After evaporation of the solvents, the resulting solid was suspended in MeCN and filtrated, affording the title compound as an off-white solid. LC/MS (Method B): 420.3 (M−H)−. HPLC (Method A) Rt 5.72 min (Purity: 99.4%).

1. customThe title compound was prepared following procedure
2. customThe reaction mixture was evaporated
3. dissolutionThe crude product was dissolved in EtOAc
4. washwashed with NH4Cl
5. dry with materialbrine and dried over MgSO4
6. customAfter evaporation of the solvents
7. filtrationfiltrated