反应详情

Title compound was prepared following procedure and work up described for Intermediate 5 step 2 but starting from methyl 4-{5-[4-bromo-3-(methoxymethyl)phenyl]-1,2,4-oxadiazol-3-yl}-2-fluorobenzoate obtained from step 1 (50 mg, 0.12 mmol) and 2-(2-methoxy-phenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (30.5 mg, 0.13 mmol) (130° C. for 10 min under microwave irradiation). Purification by flash chromatography (cHex:EtOAc, from 100:0 to 20:80) gave the title compound as a yellow powder. LC/MS (Method B): 449.2 (M+H)+.

1. customTitle compound was prepared
2. customPurification by flash chromatography (cHex:EtOAc, from 100:0 to 20:80)