Methyl iodide → 6-Amino-3-methyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

To a solution of the 6-aminopyrimidine-2,4(1H,3H)-dione (15 g, 118 mmol) in 1,1,1,3,3,3-hexamethyldisilazane (50 mL) was added ammonium sulfate (0.671 g, 5 mmol), then the resulting mixture was heated to reflux with stirring for 6 h. The mixture was concentrated to give a light-yellow solid. This solid was combined with acetonitrile (50 mL) and iodomethane (15 mL, 250 mmol) was added. The resulting mixture was stirred at 40° C. for 16 h. Then the mixture was concentrated, neutralized with saturated sodium bicarbonate to pH=7, filtered, and the filter cake was washed with brine and ethanol, dried under vacuum to give 6-amino-3-methylpyrimidine-2,4 (1H,3H)-dione (7.1 g, 42.6% yield) as yellow solid. LCMS MH+ 142.

1. temperaturethe resulting mixture was heated
2. temperatureto reflux
3. concentrationThe mixture was concentrated
4. customto give a light-yellow solid
5. additionwas added
6. stirringThe resulting mixture was stirred at 40° C. for 16 h
7. concentrationThen the mixture was concentrated
8. filtrationfiltered
9. washthe filter cake was washed with brine and ethanol
10. customdried under vacuum

ORD record

ord-e4704c2aad5245d2b7bdfac7b0a20927

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09359359B2