反应详情

(3S)-3-[(4-bromophenyl)amino]butanamide (for a preparation see Intermediate 13, 24.9 g, 97 mmol) was taken up in Ethyl acetate (850 mL) and cooled to <−9° C. (internal). Isopropyl chloroformate (116 mL, 116 mmol, Aldrich) was added followed by slow addition of Lithium tert-butoxide (18.61 g, 232 mmol) in Tetrahydrofuran (THF) (232 mL) keeping the temperature below 0° C. The reaction was stirred for 30 mins then checked by LCMS which showed a complete reaction. The mixture was partitioned between EtOAc (1000 ml) and 2N HCl (2000 ml). The organic layer was washed with brine (2000 ml) and then dried with Na2SO4, filtered and concentrated to yield the product as a brown oil (17.9 g) LCMS (Method B): Rt=1.09, MH+=343

1. temperaturecooled to <−9° C. (internal)
2. customthe temperature below 0° C
3. customa complete reaction
4. customThe mixture was partitioned between EtOAc (1000 ml) and 2N HCl (2000 ml)
5. washThe organic layer was washed with brine (2000 ml)
6. dry with materialdried with Na2SO4
7. filtrationfiltered
8. concentrationconcentrated