Potassium Phosphate, Tribasic → 5-(3-(4-fluorobenzyl)-4-oxo-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazin-6-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide

HRID 2201539Notes

Reaction equation

HRID 2201539 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:9][C:10]3[CH:20]=[C:19]([N:21]([CH3:26])[S:22]([CH3:25])(=[O:24])=[O:23])[C:18](C4C=CC=C(B5OC(C)(C)C(C)(C)O5)C=4)=[CH:17][C:11]=3[C:12]=2[C:13]([NH:15][CH3:16])=[O:14])=[CH:4][CH:3]=1.Br[C:43]1[N:52]=[CH:51][C:50]2[O:49][CH2:48][N:47]([CH2:53][C:54]3[CH:59]=[CH:58][C:57]([F:60])=[CH:56][CH:55]=3)[C:46](=[O:61])[C:45]=2[CH:44]=1.[O-]P([O-])([O-])=O.[K+].[K+].[K+]>CN(C=O)C.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[F:60][C:57]1[CH:58]=[CH:59][C:54]([CH2:53][N:47]2[C:46](=[O:61])[C:45]3[CH:44]=[C:43]([C:18]4[C:19]([N:21]([CH3:26])[S:22]([CH3:25])(=[O:24])=[O:23])=[CH:20][C:10]5[O:9][C:8]([C:5]6[CH:6]=[CH:7][C:2]([F:1])=[CH:3][CH:4]=6)=[C:12]([C:13]([NH:15][CH3:16])=[O:14])[C:11]=5[CH:17]=4)[N:52]=[CH:51][C:50]=3[O:49][CH2:48]2)=[CH:55][CH:56]=1

Participants

6

Reactant 3

HCID 62657Potassium Phosphate, TribasicHCID 674032762-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzofuran-3-carboxamideHCID 1178015676-bromo-3-(4-fluorobenzyl)-2H-pyrido[4,3-e][1,3]oxazin-4(3H)-one

Product 1

HCID 1178015485-(3-(4-fluorobenzyl)-4-oxo-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazin-6-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamideYield 57.5%

Reagents, catalysts & solvents 2

HCID 178418228Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)CatalystHCID 6228DimethylformamideSolvent

Conditions

Temperature
100 °C

Procedure

To a degassed solution of 2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)-5-(3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)benzofuran-3-carboxamide (134 mg, 0.27 mmol) and 6-bromo-3-(4-fluorobenzyl)-2H-pyrido[4,3-e][1,3]oxazin-4(3H)-one (75 mg, 0.22 mmol) in DMF (2 mL) were added Pd(dppf)Cl2 (18 mg, 0.02 mmol) and K3PO4 (331 mg, 0.66 mmol) under N2. After being stirred at 100° C. overnight, the reaction mixture was cooled to RT and filtered. The filtrate was washed with brine and dried over Na2SO4. After being concentrated, the residue was purified by prep-TLC (PE:EtOAc=1:1) to give the product of 5-(3-(4-fluorobenzyl)-4-oxo-3,4-dihydro-2H-pyrido[4,3-e][1,3]oxazin-6-yl)-2-(4-fluorophenyl)-N-methyl-6-(N-methylmethylsulfonamido)benzofuran-3-carboxamide (80 mg, yield: 57%). 1H-NMR (CDCl3, 400 MHz) δ 8.52 (s, 1H), 8.08 (s, 1H), 8.01˜7.97 (m, 3H), 7.69 (s, 1H), 7.35 (dd, J=6.0, 8.4 Hz, 2H), 7.20 (t, J=8.4 Hz, 2H), 7.08 (t, J=8.4 Hz, 2H), 5.91 (s, 1H), 5.23 (s, 2H), 4.77 (s, 2H), 3.27 (s, 3H), 3.01 (d, J=4.8 Hz, 3H), 2.85 (s, 3H). MS (M+H)+: 633.

Workup

  1. temperaturethe reaction mixture was cooled to RT
  2. filtrationfiltered
  3. washThe filtrate was washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationAfter being concentrated
  6. customthe residue was purified by prep-TLC (PE:EtOAc=1:1)

Sources & evidence

ORD record
ord-6976a23032cb4c059f4e1094a9d08dc0
Source dataset
uspto-grants-2016_06
Patent number
US09364482B2

Reaction notes

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