反应详情

温度

100 °C

A mixture of methyl 3-(benzyloxy)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)picolinate (540 mg, 0.87 mmol), LiOH.H2O (110 mg, 2.62 mmol) in 1,4-dioxane/H2O (15 mL/5 mL) under N2 was stirred at 100° C. for 1 h. After being filtrated and acidified with HCl to pH=5, the mixture was extracted with EtOAc, the organic phases were dried and concentrated to afford 3-(benzyloxy)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)picolinic acid (520 mg, yield: 98%). 1H-NMR (DMSO-d6, 400 MHz) δ 8.56 (d, J=4.8 Hz, 1H), 7.94˜8.07 (m, 3H), 7.73˜7.85 (m, 3H), 7.50 (d, J=7.2 Hz, 2H), 7.42 (t, J=7.6 Hz, 4H), 7.35 (br s, 1H), 5.30 (s, 2H), 3.20 (s, 3H), 2.94 (s, 3H), 2.82 (d, J=4.4 Hz, 3H). MS (M+H)+: 604.

1. filtrationAfter being filtrated
2. extractionthe mixture was extracted with EtOAc
3. customthe organic phases were dried
4. concentrationconcentrated