反应详情

To a suspension of methyl 3-(benzyloxy)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)picolinate (430 mg, 0.70 mmol) in MeOH (4 mL) was added 1N NaOH (2.10 ml, 2.09 mmol). The resulting mixture was stirred at RT overnight, then added 1N HCl (2.10 ml, 2.09 mmol) was added. The reaction was concentrated in vacuo. The resulting residue was treated with EtOH/DCM (1:1) and filtered to remove the solid. The filtrate was concentrated in vacuo to provide 3-(benzyloxy)-6-(2-(4-fluorophenyl)-3-(methylcarbamoyl)-6-(N-methylmethylsulfonamido)benzofuran-5-yl)picolinic acid (430 mg, yield: 102%). MS (M+H)+: 604.

1. additionwas added
2. concentrationThe reaction was concentrated in vacuo
3. additionThe resulting residue was treated with EtOH/DCM (1:1)
4. filtrationfiltered
5. customto remove the solid
6. concentrationThe filtrate was concentrated in vacuo