反应详情

Following the procedure as described in EXAMPLE 4 and making non-critical variations to replace 5-bromo-7-(4-methoxybenzyl)imidazol[1,5-a]pyrazin-8(7H)-one with 3-benzhydryl-5-bromobenzo[d]oxazol-2(3H)-one and (5-chloro-2-hydroxyphenyl)boronic acid with (2-(benzyloxy)-5-methylphenyl)boronic acid, 3-benzhydryl-5-(2-(benzyloxy)-5-methylphenyl)benzo[d]oxazol-2(3H)-one was obtained as a colorless solid in quantitative yield (1.05 g): 1H NMR (300 MHz, CDCl3) δ7.30-7.16 (m, 17H), 6.98 (dd, J=8.3, 1.7 Hz, 1H), 6.80-6.76 (m, 3H), 6.68 (s, 1H), 4.95 (s, 2H), 2.24 (s, 3H); MS (ES+) m/z 497.8 (M+1).