HRID2204355

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID71756073

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)c1c(C(=O)OCC)c(C(Nc2cc(Cl)c(=O)n(C)c2)c2ccc(Cl)cc2)n(C(C)C)c1Br

HCID86703163

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in analogy to the procedure described for Step L3 but 2-bromo-5-[(4-chloro-phenyl)-hydroxy-methyl]-1-isopropyl-1H-pyrrole-3,4-dicarboxylic acid diethyl ester (Step BM2) and 5-amino-3-chloro-1-methyl-1H-pyridin-2-one (Step E5) were used instead of 2-[(4-chloro-phenyl)-hydroxy-methyl]-1-isopropyl-1H-pyrrole-3-carboxylic acid ethyl ester and 3-amino-5-chloro-1-methyl-1H-pyridin-2-one respectively. The title compound was obtained as a blue foam. tR: 1.28 min (HPLC 3); ESI-MS: tR=1.25 min, [M+H]+ 612/614/616 (LC-MS 1); TLC: Rf=0.17 (2:1 EtOAc/heptanes).

WORKUP

后处理

customThe title compound was prepared in analogy to the procedure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-9ae43fe3256d4d959e0994dc1a3ff404
来源数据集: uspto-grants-2016_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09365576B2
来源说明: uspto-grants-2016_06

反应 SMILES

[CH2:1]([O:3][C:4]([C:6]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:9]([CH:16]([C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)O)[N:8]([CH:25]([CH3:27])[CH3:26])[C:7]=1[Br:28])=[O:5])[CH3:2].[NH2:29][C:30]1[CH:31]=[C:32]([Cl:38])[C:33](=[O:37])[N:34]([CH3:36])[CH:35]=1.C(OC(C1C=CN(C(C)C)C=1C(C1C=CC(Cl)=CC=1)O)=O)C.NC1C(=O)N(C)C=C(Cl)C=1>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])=[C:9]([CH:16]([NH:29][C:30]2[CH:31]=[C:32]([Cl:38])[C:33](=[O:37])[N:34]([CH3:36])[CH:35]=2)[C:18]2[CH:23]=[CH:22][C:21]([Cl:24])=[CH:20][CH:19]=2)[N:8]([CH:25]([CH3:27])[CH3:26])[C:7]=1[Br:28])=[O:5])[CH3:2]