反应详情

The title compound was prepared in analogy to the procedure described for Example 17 but 4-[2-bromo-5-(3-chloro-2-fluoro-phenyl)-1-isopropyl-4-oxo-1,4,5,6-tetrahydro-pyrrolo[3,4-b]pyrrol-6-yl]-benzonitrile (Intermediate I) and 2,4-dimethoxypyrimidine-5-boronic acid were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 5-cyano-2-methoxyphenylboronic acid respectively. The reaction was performed at 75° C. for 2 h and the product was purified by flash chromatography. The title compound was obtained as a white solid. tR=5.27 min (HPLC 4); ESI-MS: tR=1.13 min, [M+H]+ 532/534 (LC-MS 1); 1H-NMR (d6-DMSO, 600 MHz): 8.31 (s, 1H), 7.82 (m, 2H), 7.47 (m, 2H), 7.39-7.46 (m, 2H), 7.18 (m, 1H), 6.51 (s, 1H), 6.40 (s, 1H), 3.95 (m, 1H), 3.94 (s, 3H), 3.90 (s, 3H), 1.31 (m, 3H), 0.43 (m, 3H).

1. customThe title compound was prepared in analogy to the procedure
2. customthe product was purified by flash chromatography