反应详情

The title compound was prepared in analogy to the procedure described for Step D3 but 5-(2,4-dimethoxy-pyrimidin-5-yl)-1-isopropyl-1H-pyrrole-3-carboxylic acid methyl ester (Step 195.3) and 2-fluoro-4-formyl-benzonitrile [101048-76-4] were used instead of 5-bromo-1-isopropyl-1H-pyrrole-3-carboxylic acid methyl ester and 4-chlorobenzaldehyde respectively. The title compound was obtained as a yellow solid. tR: 1.12 min (HPLC 3); ESI-MS: tR=1.11 min, [M+H]+ 455 (LC-MS 1); TLC: Rf=0.30 (1:1 EtOAc/heptanes).

1. customThe title compound was prepared in analogy to the procedure