反应详情

The title compound was prepared in analogy to the procedure described for Example 17 but 5-bromo-1-isopropyl-1H-pyrrole-3-carboxylic acid methyl ester (Step D4) and 2,4-dimethoxypyrimidine-5-boronic acid were used instead of 2-bromo-5-(5-chloro-2-methyl-phenyl)-6-(4-chloro-phenyl)-1-isopropyl-5,6-dihydro-1H-pyrrolo[3,4-b]pyrrol-4-one and 5-cyano-2-methoxyphenylboronic acid respectively. The title compound was obtained as a yellow solid. tR: 0.97 min (HPLC 3); ESI-MS: tR=0.97 min, [M+H]+ 306 (LC-MS 1); TLC: Rf=0.43 (1:1 EtOAc/heptanes).

1. customThe title compound was prepared in analogy to the procedure