反应详情

280 mg (0.74 mmol) of the compound from Example 7A were introduced at RT together with 108.1 mg (0.89 mmol) of 4-dimethylaminopyridine in 5.3 ml of pyridine, admixed with portions of 0.31 ml (1.84 mmol) of trifluoromethanesulphonic anhydride and stirred for 12 h. The pyridine was removed on a rotary evaporator and the residue was taken up in acetonitrile and 1N hydrochloric acid. The product was purified by preparative HPLC (Method 10). This gave 230 mg (86% of theory) of the title compound.

1. customThe pyridine was removed on a rotary evaporator
2. customThe product was purified by preparative HPLC (Method 10)