Iodopentafluoroethane → 4,4,5,5,5-Pentafluoro-1-(3'-methylsulfanyl-biphenyl-4-yl)-pent-1-en-3-one

To a saturated solution of pentafluoroiodoethane (0.84 M, in diethyl ether) (203.5 mL, 162.8 mmol), was slowly added methyllithium/lithium bromide (1.5 M, in diethyl ether) (108.6 mL, 162.8 mmol) under nitrogen atmosphere at −78° C. The reaction mixture was stirred for 20 minutes and then a solution of N-methoxy-N-methyl-3-(3′-methylsulfanyl-biphenyl-4-yl)-acrylamide (17.0 g, 54.3 mmol, in tetrahydrofuran 20.0 mL) prepared in Step 1 was slowly added thereto at −78° C. The reaction mixture was stirred at room temperature, quenched with distilled water, acidified by a 10% potassium hydrogen sulfate solution (pH=5), and then extracted with diethyl ether three times. The combined extract was washed with a saturated solution of sodium hydrogen carbonate, dried on anhydrous magnesium sulfate, and then concentrated under reduced pressure to give a yellow liquid residue. The resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/30) to give 15.4 g of the titled compound as a yellow liquid.

1. customat −78° C
2. additionwas slowly added
3. customat −78° C
4. stirringThe reaction mixture was stirred at room temperature
5. customquenched with distilled water
6. extractionextracted with diethyl ether three times
7. extractionThe combined extract
8. washwas washed with a saturated solution of sodium hydrogen carbonate
9. dry with materialdried on anhydrous magnesium sulfate
10. concentrationconcentrated under reduced pressure
11. customto give a yellow liquid residue
12. customThe resulting residue was purified by silica gel column chromatography (eluent: ethyl acetate/n-hexane=1/30)

ORD record

ord-1064b2f6614d45f59c2f2b23c9fd7817

Source dataset

uspto-grants-2016_06

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09376420B2