反应详情

温度

57.5 °C

(R)-4-((R)-1-(6-chloro-3-methyl-3H-imidazo[4,5-c]pyridin-4-yloxy)ethyl)-1-((R)-1-(4-methoxyphenyl)ethyl)pyrrolidin-2-one 2.05 (32 mg, 0.075 mmol) was dissolved in trifluoroacetic acid (1.1 mL) at room temperature and mixture was heated between 55-60° C. overnight. After cooling to room temperature, mixture was concentrated under reduced pressure, taken up in ethyl acetate, washed with saturated NaHCO3 (aq), and layers separated. Aqueous layer was extracted with ethyl acetate (3×) and combined organic layers were washed with 1:1 saturated NaHCO3 (aq): brine, dried (Na2SO4), filtered, and concentrated under reduced pressure to yield (R)-4-((R)-1-(6-chloro-3-methyl-3H-imidazo[4,5-c]pyridin-4-yloxy)ethyl)pyrrolidin-2-one 2.06, which was used without further purification.

1. temperatureAfter cooling to room temperature
2. concentrationmixture was concentrated under reduced pressure
3. washwashed with saturated NaHCO3 (aq), and layers
4. customseparated
5. extractionAqueous layer was extracted with ethyl acetate (3×)
6. washwere washed with 1:1 saturated NaHCO3 (aq)
7. dry with materialbrine, dried (Na2SO4)
8. filtrationfiltered
9. concentrationconcentrated under reduced pressure