反应详情

Under a nitrogen atmosphere, a solution of diethyl azodicarboxylate (4.699 g, 26.98 mmol) in dry tetrahydrofuran (THF) (15 mL) was added drop-wise to an ice-cold stirring solution of (2S)-N-(tert-butoxycarbonyl)-2-(hydroxymethyl)pyrrolidine (5.37 g, 26.7 mmol), iodine (3.42 g, 13.5 mmol) and triphenylphosphine (7.069 g, 26.95 mmol) in dry THF (50 mL). The mixture was stirred and allowed to warm to ambient temperature overnight. The mixture was concentrated on a rotary evaporator and then the residue was stirred with 5% aqueous Na2S2O3 (50 mL). After stirring for 30 min, the mixture was extracted with dichloromethane (4×25 mL). The combined dichloromethane extracts were dried (Na2SO4), filtered and concentrated. The residue was repeatedly crystallized (three to four times) from dry ether and finally from heptane to give 3.20 g (38.6%) of product.

1. concentrationThe mixture was concentrated on a rotary evaporator
2. stirringthe residue was stirred with 5% aqueous Na2S2O3 (50 mL)
3. stirringAfter stirring for 30 min
4. extractionthe mixture was extracted with dichloromethane (4×25 mL)
5. dry with materialThe combined dichloromethane extracts were dried (Na2SO4)
6. filtrationfiltered
7. concentrationconcentrated
8. customThe residue was repeatedly crystallized (three to four times) from dry ether