反应详情

The intermediate 3-(1-ethyl-4,4,6-trimethyl-2-oxo-1,2,3,4-tetrahydro-quinolin-7-yl)-2,5-difluoro-4-methoxy-benzaldehyde was prepared in a similar manner to example 7a using 7-bromo-1-ethyl-4,4,6-trimethyl-3,4-dihydro-1H-quinoline-2-one (example 2b) and 3-bromo-2,5-difluoro-4-methoxy benzaldehyde. 14% yield. 1H NMR (300 MHz; CDCl3): 1.21 (t, J=6.9 Hz, 3 H), 1.32 (s, 3 H), 1.33 (s, 3 H), 2.13 (s, 3 H), 2.53 (s, 2 H), 3.81 (2 s, 3 H), 4.02 (q, J=6.9 Hz, 1 H), 6.81 (s, 1 H), 7.23 (s, 1 H), 7.68 (dd, J1=6.3 Hz, J2=11.7 Hz, 1 H), 10.25 (2 s, 1 H).