反应详情

0.200 g of the above prepared 3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-benzo[b]thiophen-7-yl]-2-ethoxy-3-hydroxy-propionic acid ethyl ester (0.433 mmol) was dissolved in 1.4 ml of trifluoroacetic acid, treated at 0° with 0.688 ml of triethylsilane (10 eq.) and then kept for 6 h at 0° under vigorous stirring. The reaction mixture was then poured onto crashed ice/AcOEt/NaHCO3, the organic layer washed with water (pH of aq. phase ˜8), dried over magnesium sulfate, and evaporated to dryness. Flash chromatography (SiO2, hexane/AcOEt=8/2) yielded 0.127 g of the title compound as colorless oil.

1. additionThe reaction mixture was then poured
2. washthe organic layer washed with water (pH of aq. phase ˜8)
3. dry with materialdried over magnesium sulfate
4. customevaporated to dryness