反应详情

0.125 g of the above prepared 3-[4-(2-tert-butyl-5-methyl-oxazol-4-ylmethoxy)-benzo[b]thiophen-7-yl]-2-ethoxy-propionic acid ethyl ester (0.281 mmol) was dissolved in 1.7 ml of THF/EtOH=1/1, treated with 0.840 ml of 1N NaOH (3 eq.), and kept at ambient temperature for 1.0 h. The reaction mixture was then poured onto crashed ice/AcOEt/HCl dil., the aqueous phase reextracted once more with AcOEt, the combined organic layers washed with water, dried over magnesium sulfate, and evaporated to dryness. Crystallization from hexane/AcOEt yielded finally 0.111 g of the title compound as white crystals of mp. 179–80°.

1. additionThe reaction mixture was then poured
2. washthe combined organic layers washed with water
3. dry with materialdried over magnesium sulfate
4. customevaporated to dryness
5. customCrystallization from hexane/AcOEt