反应详情

1.900 g of the above prepared (2-cyclohexyl-5-methyl-oxazol-4-yl)-acetonitrile (9.30 mmol) was dissolved in 21 ml EtOH/water=1/1 and treated with 5 eq. of NaOH-pellets (1.86 g). Hydrolysis was allowed to proceed over night at 60° C. After cooling, 25% HCl was added, followed by AcOEt. After separation of the two layers, the aq. phase was again extracted with AcOEt, the combined organic layers washed with water, dried over sodium sulfate, and evaporated to dryness to yield 1.920 g of the title acid as light-brown, waxy solid.

1. customHydrolysis
2. waitto proceed over night at 60° C
3. temperatureAfter cooling
4. customAfter separation of the two layers
5. extractionthe aq. phase was again extracted with AcOEt
6. washthe combined organic layers washed with water
7. dry with materialdried over sodium sulfate
8. customevaporated to dryness
9. customto yield 1.920 g of the title acid as light-brown, waxy solid