反应详情

0.189 g of the above prepared 3-{4-[2-(2-cyclohexyl-5-methyl-oxazol-4-yl)-ethoxy]-3,5-dimethyl-phenyl}-3-hydroxy-2-isopropoxy-propionic acid ethyl ester (0.388 mmol) was dissolved in 1.5 ml of trifluoroacetic acid, treated at 0° with 0.620 ml of triethylsilane (10 eq.) and then kept for 32 h at RT under vigorous stirring. The reaction mixture was then poured onto crashed ice/AcOEt/NaHCO3, the organic layer washed with water (pH of aq. Phase ˜9), dried over sodium sulfate, and evaporated to dryness. Flash chromatography (SiO2, hexane/AcOEt=8/2) produced 0.182 g of the title compound as colorless oil.

1. additionThe reaction mixture was then poured
2. washthe organic layer washed with water (pH of aq. Phase ˜9)
3. dry with materialdried over sodium sulfate
4. customevaporated to dryness