HRID2216132

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8082

Piperidine

C5H11N

结构：CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CCCCCCCCCCNC(=O)OCC2c3ccccc3-c3ccccc32)c1

HCID145857666

未命名化合物

PRODUCTS

生成物

结构：CSc1sc(C(=N)NC(=O)OC(C)(C)C)cc1S(=O)(=O)c1cccc(-c2c(C)cccc2NC(=O)CCCCCCCCCCN)c1

HCID145857685

未命名化合物

收率 79.6%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6228

N,N-Dimethylformamide

C3H7NO

PROCEDURE

实验过程

A solution of 50% piperidine in DMF [1 mL] was added to (10-{3′-[5-(tert-butoxycarbonylamino-imino-methyl)-2-methylsulfanyl-thiophene-3-sulfonyl]-6-methyl-biphenyl-2-ylcarbamoyl}-decyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (0.040 g, 0.043 mmol) [example 211, step a] and stirred for 0.5 hours, followed by evaporation. Column chromatography (10% MeOH in dichloromethane) of the residue yielded the title compound (0.024 g, 77%) as a solid. ESI-MS (m/z): Calcd. for C35H48N4O5S3: 700.28; found: 701.0.

WORKUP

后处理

customfollowed by evaporation

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5333f9c14ecf41ac96b75b775a4a1316
来源数据集: uspto-grants-2006_09
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07109354B2
来源说明: uspto-grants-2006_09

反应 SMILES

N1CCCCC1.C1C2C(COC(=O)[NH:23][CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][C:34](=[O:69])[NH:35][C:36]3[CH:41]=[CH:40][CH:39]=[C:38]([CH3:42])[C:37]=3[C:43]3[CH:48]=[CH:47][CH:46]=[C:45]([S:49]([C:52]4[CH:56]=[C:55]([C:57]([NH:59][C:60]([O:62][C:63]([CH3:66])([CH3:65])[CH3:64])=[O:61])=[NH:58])[S:54][C:53]=4[S:67][CH3:68])(=[O:51])=[O:50])[CH:44]=3)C3C(=CC=CC=3)C=2C=CC=1>CN(C=O)C>[C:63]([O:62][C:60](=[O:61])[NH:59][C:57]([C:55]1[S:54][C:53]([S:67][CH3:68])=[C:52]([S:49]([C:45]2[CH:44]=[C:43]([C:37]3[C:38]([CH3:42])=[CH:39][CH:40]=[CH:41][C:36]=3[NH:35][C:34](=[O:69])[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][NH2:23])[CH:48]=[CH:47][CH:46]=2)(=[O:51])=[O:50])[CH:56]=1)=[NH:58])([CH3:66])([CH3:65])[CH3:64]