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HRID221638

反应详情

EQUATION

反应方程式

HRID 221638 的结构方程式

REACTANTS

反应物

2
结构：COCOc1ccc(OC[C@@H]2CO2)cc1
HCID44126707

未命名化合物

结构：NC1CCN(c2ncnc3scc(-c4ccccc4)c23)CC1
HCID69041562

未命名化合物

PRODUCTS

生成物

1
结构：Oc1ccc(OC[C@@H](O)CNC2CCN(c3ncnc4scc(-c5ccccc5)c34)CC2)cc1
HCID24936487

未命名化合物

收率 58%

PROCEDURE

实验过程

Synthesis followed SP6 (4 h), using 250 μmol (S)-2-((4-(methoxymethoxy)phenoxy)methyl)oxirane and 1-(5-phenylthieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give O-MOM intermediate upon purification by prep. TLC (2 mm silica gel, PE/CH2Cl2/MeOH 4:6:1) with 58% yield. Product was obtained by MOM removal according to SP8 (1.5 eq. TosOH, 10 h) and purification by prep. TLC (1 mm silica gel, CH2Cl2/MeOH 90:10) with 61% yield.

WORKUP

后处理

  1. customSynthesis
  2. customSP6 (4 h)
  3. customto give O-MOM intermediate
  4. customupon purification by prep
  5. customProduct was obtained by MOM removal
  6. customaccording to SP8 (1.5 eq. TosOH, 10 h) and purification by prep