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HRID221643

反应详情

EQUATION

反应方程式

HRID 221643 的结构方程式

REACTANTS

反应物

2
结构：Cc1cc(C)nc(N2CCC(N)CC2)n1
HCID4778289

1-(4,6-Dimethyl-2-pyrimidinyl)-4-piperidinamine

C11H18N4

结构：CC(C)(C)[Si](C)(C)Oc1ccc(OCC2CO2)cc1
HCID19385012

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(C)nc(N2CCC(NCC(O)COc3ccc(O)cc3)CC2)n1
HCID24937138

未命名化合物

收率 64%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(C)O.CS(C)=O
溶剂HCID87082799

未命名化合物

PROCEDURE

实验过程

Synthesis followed SP6 (iPrOH:DMSO 1:1, 120° C., 35 h), using 200 μmol tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane and 1-(4,6-dimethylpyrimidin-2-yl)piperidin-4-amine to give O-silylated intermediate upon purification by prep. HPLC (reversed phase) and prep. TLC (1 mm silica gel, PE/CH2Cl2/MeOH 6:4:1) with 64% yield. Product was obtained by deprotection according to SP7 and purification by prep. HPLC (reversed phase) and prep. TLC (1 mm silica gel, PE/CH2Cl2/MeOH 3:7:1.5) with 10% yield.

WORKUP

后处理

  1. customSynthesis
  2. customto give O-silylated intermediate
  3. customupon purification by prep
  4. customProduct was obtained by deprotection
  5. customaccording to SP7 and purification by prep