反应详情

Synthesis followed SP6 (5 h), using 150 μmol tert-butyldimethyl(4-(oxiran-2-ylmethoxy)phenoxy)silane and 1-(5-(2-thienyl)thieno[2,3-d]pyrimidin-4-yl)piperidin-4-amine to give O-silylated intermediate upon purification by prep. HPLC (reversed phase) and prep. TLC (1 mm silica gel, CH2Cl2MeOH 95:5) with 27% yield. Product was obtained by deprotection according to SP7 and purification by prep. HPLC (reversed phase) with 27% yield.

1. customSynthesis
2. customSP6 (5 h)
3. customto give O-silylated intermediate
4. customupon purification by prep
5. customProduct was obtained by deprotection
6. customaccording to SP7 and purification by prep