反应详情

温度

100 °C

5-Chloro-4-methylpyridine-2,3-diamine (prepared by a method similar to Example 206a) (2.0 g, 12.7 mmol) was dissolved in DMF (40 ml) and heated to 100° C. 3-Hydroxy-4-nitrobenzaldehyde (2.10 g, 12.7 mmol) dissolved in DMF (10 ml) was added slowly (10 min). Air was bubbled through the reaction mixture. After 16 h, the DMF was evaporated off and the residue was purified by column chromatography (EtOAc/methanol, 10:1) giving the title compound (0.7 g, 18%).

1. additionwas added slowly (10 min)
2. customAir was bubbled through the reaction mixture
3. customthe DMF was evaporated off
4. customthe residue was purified by column chromatography (EtOAc/methanol, 10:1)