反应详情

To a solution of benzyl 4′-{2-[(1S,2R)-2-(4-benzyloxy-3-methanesulfonylaminophenyl)-2-hydroxy-1-methylethylamino]ethoxy}-3′,5′-dimethylbiphenyl-4-carboxylate (0.074 g) in N,N-dimethylformamide (4 mL) was added 10% palladium-carbon (0.05 g), and the mixture was stirred at room temperature for 1.5 hrs under an atmosphere of hydrogen. The catalyst was removed by filtration, and the solvent was evaporated under reduced pressure. Methylene chloride was added to the residue, and the resulting precipitated materials were collected by filtration. The crude product was purified by ODS column chromatography (eluent: acetonitrile/water=1/1) to afford the title compound (0.036 g).

1. customThe catalyst was removed by filtration
2. customthe solvent was evaporated under reduced pressure
3. additionMethylene chloride was added to the residue
4. customthe resulting precipitated materials
5. filtrationwere collected by filtration
6. customThe crude product was purified by ODS column chromatography (eluent: acetonitrile/water=1/1)