反应详情

A mixture of pyridine-3-carbaldehyde (26.26 g), 2,3-butanedione-2-oxime (24.77 g) and 4N hydrogenchloride-ethyl acetate solution (300 mL) was stirred at room temperature for 3 days. The reaction mixture was concentrated, and the obtained crystals were washed with diethyl ether. To the crystals was added tetrahydrofuran (250 mL), and a solution of thionyl chloride (43.78 g) in tetrahydrofuran (50 mL) was further added. The mixture was heated under reflux for 3 hrs. The reaction mixture was concentrated and ethyl acetate was added to the residue. The ethyl acetate layer was washed successively with saturated aqueous sodium hydrogen carbonate solution and saturated brine, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to give 3-(4-chloromethyl-5-methyl-1,3-oxazol-2-yl)pyridine as colorless crystals (9.48 g, 19%) from a fraction eluted with ethyl acetate-hexane (1:1, v/v). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 87-88° C.

1. concentrationThe reaction mixture was concentrated
2. washthe obtained crystals were washed with diethyl ether
3. additionTo the crystals was added tetrahydrofuran (250 mL)
4. additiona solution of thionyl chloride (43.78 g) in tetrahydrofuran (50 mL) was further added
5. temperatureThe mixture was heated
6. temperatureunder reflux for 3 hrs
7. concentrationThe reaction mixture was concentrated
8. additionethyl acetate was added to the residue
9. washThe ethyl acetate layer was washed successively with saturated aqueous sodium hydrogen carbonate solution and saturated brine
10. dry with materialdried over anhydrous magnesium sulfate
11. concentrationconcentrated