反应详情

A mixture of {1-benzyl-3-[(3-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)oxy]-1H-pyrazol-4-yl}methanol (0.51 g), activated manganese dioxide (1.50 g) and tetrahydrofuran (50 mL) was stirred at room temperature for 3 days. Manganese dioxide was removed by filtration and the filtrate was concentrated. The obtained crystals were collected by filtration to give 1-benzyl-3-[(3-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}benzyl)oxy]-1H-pyrazole-4-carbaldehyde (0.50 g, yield 96%). Recrystallization from ethyl acetate-hexane gave colorless prism crystals. melting point: 135-136° C.

1. customManganese dioxide was removed by filtration
2. concentrationthe filtrate was concentrated
3. filtrationThe obtained crystals were collected by filtration