反应详情

A mixture of {1-benzyl-3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-methoxybenzyl)oxy]-1H-pyrazol-4-yl}methanol (0.17 g), activated manganese dioxide (0.50 g) and tetrahydrofuran (10 mL) was stirred at room temperature for 2 hrs. Manganese dioxide was removed by filtration and the filtrate was concentrated. The obtained crystals were collected by filtration to give 1-benzyl-3-[(4-{[2-(2-furyl)-5-methyl-1,3-oxazol-4-yl]methoxy}-2-methoxybenzyl)oxy]-1H-pyrazole-4-carbaldehyde (0.12 g, yield 71%). Recrystallization from ethyl acetate-hexane gave colorless needle crystals. melting point: 147-148° C.

1. customManganese dioxide was removed by filtration
2. concentrationthe filtrate was concentrated
3. filtrationThe obtained crystals were collected by filtration