反应详情

A mixture of [3-({6-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]-3-phenyl-1-benzofuran-2-yl}methoxy)-1-phenyl-1H-pyrazol-4-yl]methanol (0.22 g), activated manganese dioxide (0.75 g) and tetrahydrofuran (10 mL) was stirred at room temperature for 3 hrs. Manganese dioxide was removed by filtration and the filtrate was concentrated. The obtained crystals were collected by filtration to give 3-({6-[(5-methyl-2-phenyl-1,3-oxazol-4-yl)methoxy]-3-phenyl-1-benzofuran-2-yl}methoxy)-1-phenyl-1H-pyrazole-4-carbaldehyde as colorless crystals (0.19 g, yield 86%). Recrystallization from ethyl acetate-hexane gave colorless needle crystals. melting point: 176-177° C.

1. customManganese dioxide was removed by filtration
2. concentrationthe filtrate was concentrated
3. filtrationThe obtained crystals were collected by filtration