反应详情

The title compound was prepared by following step E in Example 13, except that the reagent [(methoxy{[(3S,3aS,6R,6aS)-6-(nitrooxy)hexahydrofuro[3,2-b]furan-3-yl]oxy}phosphoryl)oxy]methyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate was replaced by (diethoxyphosphoryl)methyl 2-butyl-4-chloro-1-{[2′-(1-trityl-1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazole-5-carboxylate. 1H NMR (500 MHz, CDCl3) δ 8.00 (dd, J=7.7, 1.3 Hz, 1H), 7.57 (t, J=7.4 Hz, 1H), 7.50 (td, J=7.6, 1.4 Hz, 1H), 7.44 (d, J=7.8 Hz, 1H), 7.12 (d, J=8.2 Hz, 2H), 6.87 (d, J=8.0 Hz, 2H), 5.45 (s, 2H), 4.48 (d, J=8.9 Hz, 2H), 4.11 (quintet, J=7.3 Hz, 4H), 2.71 (t, J=7.8 Hz, 2H), 1.73 (quintet, J=7.7 Hz, 2H), 1.39 (sextet, J=7.4 Hz, 2H), 1.30 (t, J=7.1 Hz, 6H), 0.90 (t, J=7.5 Hz, 3H); LC-MS: m/z 587.1 (M+H).