huagongshe.com
HRID2230226

反应详情

EQUATION

反应方程式

HRID 2230226 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(C)OC(=O)C[C@H](N)c1ccc2c(c1)OCO2
HCID57048399

未命名化合物

结构：CC(C)C[C@@H](C(=O)[O-])N1C(=O)N(Cc2ccccc2)[C@@](C)(c2ccccc2)C1=O
HCID131723411

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)C[C@@H](C(=O)N[C@@H](CC(=O)O)c1ccc2c(c1)OCO2)N1C(=O)N(Cc2ccccc2)[C@@](C)(c2ccccc2)C1=O
HCID59902377

未命名化合物

PROCEDURE

实验过程

The compound was prepared analogously to Example 1 by reaction of 169.5 with tert-butyl (S)-3-amino-3-(3,4-methylenedioxyphenyl)propionate (prepared analogously to S. G. Davis et al., Tetrahedron Asymmetry 1991, 2, 183), cleavage of the tert-butyl ester with trifluoroacetic acid as described in Example 1, and subsequent purification of the crude product by means of preparative HPLC (RP18: eluent: acetonitrile/water=50/120). ES(+)-MS: 586.4 (M+H)+

WORKUP

后处理

  1. customprepared analogously to S
  2. customDavis et al., Tetrahedron Asymmetry 1991, 2, 183), cleavage of the tert-butyl ester with trifluoroacetic acid as described in Example 1, and subsequent purification of the crude product by means of preparative HPLC (RP18: eluent: acetonitrile/water=50/120)