反应详情

Into a 3-neck reaction flask equipped with a mechanical stirrer, was added 8-chloro-2-(2,4-difluorophenyl)imidazo[1,2-a]pyrazine (40.00 g, 150.6 mmol), ferric acetylacetonate (2.66 g, 7.53 mmol), tetrahydrofuran (970 mL) and N-methylpyrrolidinone (86 mL). The flask was charged with nitrogen and cooled to about −5-0° C. (acetone/DriKold cooling bath) before the drop-wise addition of 3M MeMgBr in Et2O (150 mL) over about 20 min. After the addition was complete, the reaction was stirred at this temperature for about 15 min before the cooling bath was removed. The reaction mixture was allowed to warm to ambient temperature over about 1 hour and then stirred overnight. The reaction was concentrated and the residue was stirred with water (1000 mL) and EtOAc (1000 mL) for about 15 min. The mixture was filtered through a Celite® pad to remove salts. The Celite® pad was scraped and stirred with EtOAc (3×250 mL). The basic aqueous phase was separated and extracted with EtOAc (3×250 mL). The organic layers were combined, washed with water (3×350 mL), dried over MgSO4, and filtered through a Florisil® pad to remove origin material. The solvent was removed to yield a yellow solid that was treated with boiling MeOH (125 mL), cooled to about 15° C. and petroleum ether [bp 30-60° C.] (250 mL) was added with stirring. The solid was filtered, washed with petroleum ether [bp 30-60° C.] (3×50 mL), and dried in vacuo at 70° C. to yield the title compound as a pale yellow powdery solid (23.25 g, 64%): LC/MS (Table 1, Method g) Rt=2.42 min; MS m/z: 246.1 (M+H)+.

1. customInto a 3-neck reaction flask equipped with a mechanical stirrer
2. additionThe flask was charged with nitrogen
3. additionAfter the addition
4. customwas removed
5. stirringstirred overnight
6. concentrationThe reaction was concentrated
7. stirringthe residue was stirred with water (1000 mL) and EtOAc (1000 mL) for about 15 min
8. filtrationThe mixture was filtered through a Celite® pad
9. customto remove salts
10. stirringstirred with EtOAc (3×250 mL)
11. customThe basic aqueous phase was separated
12. extractionextracted with EtOAc (3×250 mL)
13. washwashed with water (3×350 mL)
14. dry with materialdried over MgSO4
15. filtrationfiltered through a Florisil® pad
16. customto remove origin material
17. customThe solvent was removed
18. customto yield a yellow solid that
19. temperaturecooled to about 15° C.
20. stirringwith stirring
21. filtrationThe solid was filtered
22. washwashed with petroleum ether [bp 30-60° C.] (3×50 mL)
23. customdried in vacuo at 70° C.