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HRID2235238

反应详情

EQUATION

反应方程式

HRID 2235238 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@H](N2CCC(Cc3c(Cl)cc(OCc4ccccc4)cc3Cl)C2=O)CC1
HCID178455343

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)[Si](C)(C)O[C@H]1CC[C@@H](N2CCC(Cc3c(Cl)cc(O)cc3Cl)C2=O)CC1
HCID178455342

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[OH-].[OH-].[Pd+2]
催化剂HCID9942167

Palladium hydroxide

H2O2Pd

结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

Combine 2 g (3.6 mmol) of 3-(4-benzyloxy-2,6-dichloro-benzyl)-1-[cis-4-(tert-butyl-dimethyl-silanyloxy)-cyclohexyl]-pyrrolidin-2-one (Preparation 71) with 150 mg Pd(OH)2 and 25 mL THF. Hydrogenate with a balloon of H2 for 3 hours. Filter the reaction through Celite®, concentrate under vacuum and purify by chromatography using CHCl3/MeOH 98/2 to recover 1.54 g (88%) of the title compound as an oil.

WORKUP

后处理

  1. filtrationFilter
  2. customthe reaction through Celite®
  3. concentrationconcentrate under vacuum
  4. custompurify by chromatography
  5. customto recover 1.54 g (88%) of the title compound as an oil