反应详情

To 0.200 (0.586 mmol) of 2,4,6-trimethyl-N-(7-nitro-1,3-benzothiazol-2-yl)benzamide in 5 mL of THF was added a pipet tip of Raney nickel. The reaction was kept under a hydrogen atmosphere via a balloon and stirred at room temperature for 90 min. The catalyst was removed via filtration and the filtrate was concentrated in vacuo to give a burnt orange solid. The resulting crude solid was purified by flash chromatography eluting with 25% ethyl acetate/hexanes mixture to give 0.118 g (65%) of the title compound as a light yellow powder.

1. customThe catalyst was removed via filtration
2. concentrationthe filtrate was concentrated in vacuo
3. customto give a burnt orange solid
4. customThe resulting crude solid was purified by flash chromatography
5. washeluting with 25% ethyl acetate/hexanes mixture