Phenol, 3,5-dipropoxy- → HCID 11591840, compound

HRID 2239664Notes

Reaction equation

HRID 2239664 reaction equation
Br[CH2:2][CH2:3][CH2:4][NH:5][C:6]1[C:7](=[O:23])[N:8]([C:19]([CH3:22])([CH3:21])[CH3:20])[S:9](=[O:18])(=[O:17])[C:10]=1[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1.[CH2:24]([O:27][C:28]1[CH:29]=[C:30]([OH:38])[CH:31]=[C:32]([O:34][CH2:35][CH2:36][CH3:37])[CH:33]=1)[CH2:25][CH3:26]>>[C:19]([N:8]1[C:7](=[O:23])[C:6]([NH:5][CH2:4][CH2:3][CH2:2][O:38][C:30]2[CH:31]=[C:32]([O:34][CH2:35][CH2:36][CH3:37])[CH:33]=[C:28]([O:27][CH2:24][CH2:25][CH3:26])[CH:29]=2)=[C:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[S:9]1(=[O:18])=[O:17])([CH3:22])([CH3:21])[CH3:20]

Participants

3

Reactant 2

HCID 119929Phenol, 3,5-dipropoxy-HCID 67242780HCID 67242780, compound

Product 1

HCID 11591840HCID 11591840, compound

Procedure

The title compound was prepared from 4-[(3-bromopropyl)amino]-2-tert-butyl-5-phenylisothiazol-3(2H)-one 1,1-dioxide and 3,5-dipropoxyphenol in a similar manner as described for Example 5. 1H NMR (500 MHz, CDCl3): δ 7.54-7.50 (m, 2H), 7.46-7.41 (m, 3H), 6.12-6.09 (m, 1H), 6.08-6.06 (m, 2H), 5.89-5.83 (m, 1H), 3.93-3.84 (m, 6H), 3.09-3.03 (m, 2H), 1.87-1.76 (m, 6H), 1.74 (s, 9H), 1.07-1.01 (m, 6H); 13C NMR (125 MHz, CDCl3): δ 161.2, 160.2, 159.9, 135.4, 131.8, 129.7, 128.8, 125.3, 107.1, 94.8, 94.6, 94.4, 94.0, 69.8, 66.4, 61.6, 42.7, 28.8, 27.8, 22.8, 10.8; Mass Spectrum: M+H+ 531.

Sources & evidence

ORD record
ord-7c4eb6d81e564f079302cfab52a3fb2f
Source dataset
uspto-grants-2010_05
Patent number
US07723333B2

Reaction notes

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