反应详情

温度

80 °C

To a solution of N-ethyl-N′-(6-fluoro-3,4′-bipyridin-2′-yl)urea (Intermediate 32, 360 mg, 1.38 mmol) in DMF (7 mL), N-bromosuccinamide (246 mg, 1.38 mmol) was added. The resulting solution was heated to 80° C. and stirred at that temperature for 2 hours. Then the reaction was partitioned between water and ethyl acetate. The layers separated, and the organic layer was washed with 5% sodium thiosulfate solution, water and brine, then dried over magnesium sulfate and concentrated. The solid obtained was washed with acetonitrile and dried to give the title compound as an off-white solid (390 mg). MS (ESP): 340 (M+1) for C13H12FN4O; NMR: 1.07 (t, 3H); 3.12-3.18 (m, 2H); 7.36-7.40 (m, 2H); 7.68 (s, 1H); 8.15 (t, 1H); 8.34 (d, 1H); 8.47 (s, 1H); 9.36 (s, 1H).

1. customThen the reaction was partitioned between water and ethyl acetate
2. customThe layers separated
3. washthe organic layer was washed with 5% sodium thiosulfate solution, water and brine
4. dry with materialdried over magnesium sulfate
5. concentrationconcentrated
6. customThe solid obtained
7. washwas washed with acetonitrile
8. customdried