反应详情

Stir, at room temperature under argon, a mixture of 2.0 g of 4-(6-chloro-1H-benzimidazol-2-yl)-9H-fluoren-9-one, 1.26 g of hydroxylamine hydrochloride and 2.48 g of sodium acetate in 100 ml of ethanol. The following day, evaporate the reaction medium to dryness under vacuum, take the residue up with 100 ml of dichloromethane and wash with 100 ml of water. The organic phase is dried over magnesium sulphate and evaporated to dryness under vacuum. After drying at 40° C. under vacuum, we obtain 1.88 g of 4-(6-chloro-1H-benzimidazol-2-yl)-9H-fluoren-9-one oxime (Z, E) in the form of a beige solid with the following characteristics:

1. customThe following day, evaporate the reaction medium to dryness under vacuum
2. washwash with 100 ml of water
3. dry with materialThe organic phase is dried over magnesium sulphate
4. customevaporated to dryness under vacuum
5. customAfter drying at 40° C. under vacuum, we