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HRID224599

反应详情

EQUATION

反应方程式

HRID 224599 的结构方程式

REACTANTS

反应物

2
结构：Cc1cnc(N)s1
HCID351770

2-Amino-5-methyl-thiazole

C4H6N2S

结构：COC(=O)C1=C(O)c2cc(C)ccc2S(=O)(=O)N1C
HCID54696079

未命名化合物

PRODUCTS

生成物

1
结构：Cc1ccc2c(c1)C(O)=C(C(=O)Nc1ncc(C)s1)N(C)S2(=O)=O
HCID54694221

2,6-Dimethyl-4-hydroxy-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3-carboxamide-1,1-dioxide

C15H15N3O4S2

AUXILIARIES

试剂、催化剂与溶剂

1
结构：Cc1ccccc1C
溶剂HCID7237

o-Xylene

C8H10

PROCEDURE

实验过程

4.0 gm (14 millimols) of methyl 4-hydroxy-2,6-dimethyl-2H-1,2-benzothiazine-3-carboxylate-1,1-dioxide and 2.0 gm (17 millimols) of 2-amino-5-methyl-thiazole were refluxed in 200 ml of anhydrous xylene for 24 hours. After cooling, the crystals which had separated out were filtered off. After recrystallization from ethylene chloride 3.6 gm (70% of theory) of 2,6-dimethyl-4-hydroxy-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3carboxamide-1,1-dioxide were obtained.

WORKUP

后处理

  1. temperatureAfter cooling
  2. customthe crystals which had separated out
  3. filtrationwere filtered off
  4. customAfter recrystallization from ethylene chloride 3.6 gm (70% of theory) of 2,6-dimethyl-4-hydroxy-N-(5-methyl-2-thiazolyl)-2H-1,2-benzothiazine-3carboxamide-1,1-dioxide
  5. customwere obtained