1-(6-Bromopyridin-3-yl)piperazine → HCID 60209561, compound

HRID 2246214Notes

Reaction equation

HRID 2246214 reaction equation
[Br:1][C:2]1[N:7]=[CH:6][C:5]([N:8]2[CH2:13][CH2:12][NH:11][CH2:10][CH2:9]2)=[CH:4][CH:3]=1.C1([O:20][C:21]([O:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=O)C=CC=CC=1>>[Br:1][C:2]1[N:7]=[CH:6][C:5]([N:8]2[CH2:9][CH2:10][N:11]([C:21]([O:23][CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])=[O:20])[CH2:12][CH2:13]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 98780901-(6-Bromopyridin-3-yl)piperazineHCID 12094709Ethyl [(phenoxycarbonyl)oxy]acetate

Product 1

HCID 60209561HCID 60209561, compound

Procedure

The process is performed as described in Example 1 (step 1.2.). Starting with 3.57 g (14.76 mmol) of 1-(6-bromo-3-pyridyl)piperazine, obtained in step 7.3., and 3.97 g (17.71 mmol) of ethyl [(phenyloxycarbonyl)oxy]acetate, prepared in step 1.1. of Example 1, and after chromatography on silica gel, eluting with a 99/1 and then 98/2 mixture of dichloromethane and methanol, 3.75 g of product are obtained in the form of a yellow oil that crystallizes at room temperature.

Workup

  1. customobtained in step 7.3
  2. washof Example 1, and after chromatography on silica gel, eluting with a 99/1
  3. addition98/2 mixture of dichloromethane and methanol, 3.75 g of product
  4. customare obtained in the form of a yellow oil
  5. customthat crystallizes at room temperature

Sources & evidence

ORD record
ord-87bf9790b7f14b0d9a3067146088a8c2
Source dataset
uspto-grants-2010_03
Patent number
US07687503B2

Reaction notes

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