反应详情

The process is performed as described in Example 1 (step 1.2.). Starting with 3.57 g (14.76 mmol) of 1-(6-bromo-3-pyridyl)piperazine, obtained in step 7.3., and 3.97 g (17.71 mmol) of ethyl [(phenyloxycarbonyl)oxy]acetate, prepared in step 1.1. of Example 1, and after chromatography on silica gel, eluting with a 99/1 and then 98/2 mixture of dichloromethane and methanol, 3.75 g of product are obtained in the form of a yellow oil that crystallizes at room temperature.

1. customobtained in step 7.3
2. washof Example 1, and after chromatography on silica gel, eluting with a 99/1
3. addition98/2 mixture of dichloromethane and methanol, 3.75 g of product
4. customare obtained in the form of a yellow oil
5. customthat crystallizes at room temperature