反应详情

To a flask containing 4-amino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-3-nitro-pyridine-2-carbonitrile (5 g, 14.2 mmol) and 10% Pd-C (wet) (5 g) under nitrogen was added ethyl acetate (500 ml). The vessel was purged with hydrogen and stirred at room temperature for 1.5 h before filtration through a cellite pad followed by concentration under reduced pressure to afford 3,4-diamino-6-(4-ethoxy-3-trifluoromethyl-phenyl)-pyridine-2-carbonitrile (2.5 g). 1H NMR (DMSO): δ 8.02 (m, 2H), 7.31 (d, 1H), 7.14 (s, 1H), 6.1 (bs, 2H), 5.69 (bs, 2H), 4.25 (q, 2H), 1.35 (t, 3H). MS m/z 323.3 (M+1).

1. customThe vessel was purged with hydrogen
2. concentrationfollowed by concentration under reduced pressure