反应详情

To a solution of 29.7 g. (72 mMol) 3-[2-(4-chlorobenzenesulphonamido)-ethyl]-phenoxymalonic acid (preparation see Example 10 e)) in 150 ml. anhydrous tetrahydrofuran are added 14.8 g. (72 mMol) dicyclohexylcarbodiimide. The reaction mixture is stirred for 10 minutes and then a weak current of ammonia is passed in for about 1 hour. It is then left to stand for 2 hours and filtered. The mother liquor is evaporated and the residue recrystallised from isohexane. There are obtained 18.0 g. (68% of theory) of colourless crystals; m.p. 113° C.

1. customis passed in for about 1 hour
2. waitIt is then left
3. waitto stand for 2 hours
4. filtrationfiltered
5. customThe mother liquor is evaporated
6. customthe residue recrystallised from isohexane
7. customThere are obtained 18.0 g