反应详情

Ethyl 3-(2-chloro-5,6-dimethyl-3-pyridyl)acrylate (32.7 gZ) in ethanol (500 ml) was hydrogenated at 25°-30° and 344 kPa using palladium-on-charcoal catalyst (5%, 3 g). The mixture was filtered and the filtrate was evaporated to an oil which was partitioned between chloroform and 2 N hydrochloric acid. The aqueous phase was made basic with aqueous sodium hyroxide, extracted with chloroform and the chloroform extracts were evaporated to give ethyl 3-(5,6-dimethyl-3-pyridyl)propionate (21.8 g, 80%) as an oil.

1. customwas hydrogenated at 25°-30°
2. filtrationThe mixture was filtered
3. customthe filtrate was evaporated to an oil which
4. customwas partitioned between chloroform and 2 N hydrochloric acid
5. extractionextracted with chloroform
6. customthe chloroform extracts were evaporated