反应详情

A mixture of 1.93 parts of 2-ethenylpyridine, 5 parts of 9-[(4-fluorophenyl)methyl]-N-(4-piperidinyl)-9H-purin-8-amine and 80 parts of 1-butanol was stirred and refluxed overnight. The reaction mixture was evaporated. The residue was purified by column chromatography over silica gel using first a mixture of trichloromethane and methanol (95:5 by volume) and then a mixture of trichloromethane and methanol, saturated with ammonia (95:5 by volume) as eluent. The pure fractions were collected and the eluent was evaporated. The residue was crystallized from acetonitrile, yielding 1 part (15%) of 9-[(4-fluorophenyl)methyl]-N-[1-[2-(2-pyridinyl)ethyl]-4-piperidinyl]-9H-purin-8-amine; mp. 172.3° C. (compound 141).

1. temperaturerefluxed overnight
2. customThe reaction mixture was evaporated
3. customThe residue was purified by column chromatography over silica gel using first
4. additiona mixture of trichloromethane and methanol (95:5 by volume)
5. additiona mixture of trichloromethane and methanol
6. customThe pure fractions were collected
7. customthe eluent was evaporated
8. customThe residue was crystallized from acetonitrile