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HRID2250190

反应详情

EQUATION

反应方程式

HRID 2250190 的结构方程式

REACTANTS

反应物

4
结构：COC(=O)[C@@H](Cc1ccc2nc(C)n(S(=O)(=O)CC[Si](C)(C)C)c2c1)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1
HCID58864274

未命名化合物

结构：COC(=O)[C@@H](Cc1ccc2c(c1)nc(C)n2S(=O)(=O)CC[Si](C)(C)C)NC(=O)N1CCC(N2Cc3ccccc3NC2=O)CC1
HCID58864319

未命名化合物

结构：C[Si](C)(C)CCS(=O)(=O)n1ncc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)O)ccc21
HCID58864337

未命名化合物

结构：C1CCOC1.CO.O.[Li+].[OH-]
HCID68706663

未命名化合物

PRODUCTS

生成物

1
结构：Cc1nc2cc(C[C@@H](NC(=O)N3CCC(N4Cc5ccccc5NC4=O)CC3)C(=O)O)ccc2[nH]1
HCID178432157

未命名化合物

PROCEDURE

实验过程

The 1:1 mixture of (R)-3-[2-Methyl-1-(2-trimethylsilanyl -ethanesulfonyl)-1H-benzoimidazol-5-yl]-2-{[4-(2-oxo-1,4-dihydro-2H -quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid methyl ester and (R)-3-[2-Methyl-3-(2-trimethylsilanyl-ethanesulfonyl)-3H-benzoimidazol-5-yl]-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-propionic acid methyl ester was treated as described above for (R)-2-{[4-(2-oxo-1,4-dihydro-2H-quinazolin-3-yl)-piperidine-1-carbonyl]-amino}-3-[1-(2-trimethylsilanyl-ethanesulfonyl)-1H-indazol-5-yl]-propionic acid. The hydrolysis conditions (lithium hydroxide/methanol-tetrahydrofuran-water (1:1:1) at −15° C. overnight were used. The title compound was obtained as a white solid (25%). Mass spec.: 477.24 (MH)+.

WORKUP

后处理

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