反应详情

To a solution of 2-bromo-4-[3-(ethoxycarbonyl)-7-ethyl-2-methylpyrrolo[1,2-b]pyridazin-4-yl]benzoic acid (50.0 mg) in tetrahydrofuran (1 mL) was added a solution of 1 M borane-tetrahydrofuran complex (0.348 mL) in an ice bath. After stirring for 2 hours at room temperature, additional solution of the borane-tetrahydrofuran complex (0.348 mL) was added. The mixture was stirred for 15 hours at room temperature. The mixture was partitioned between ethyl acetate and 1 N hydrochloric acid. The organic layer was washed with water, saturated sodium bicarbonate, and brine, dried over magnesium sulfate, and evaporated to give ethyl 4-[3-bromo-4-(hydroxymethyl)phenyl]-7-ethyl-2-methylpyrrolo[1,2-b]pyridazine-3-carboxylate as an yellow oil (54.2 mg).

1. additionadditional solution of the borane-tetrahydrofuran complex (0.348 mL) was added
2. stirringThe mixture was stirred for 15 hours at room temperature
3. customThe mixture was partitioned between ethyl acetate and 1 N hydrochloric acid
4. washThe organic layer was washed with water, saturated sodium bicarbonate, and brine
5. dry with materialdried over magnesium sulfate
6. customevaporated