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HRID2250818

反应详情

EQUATION

反应方程式

HRID 2250818 的结构方程式

REACTANTS

反应物

1
结构：C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)C=Cc1cccc([N+](=O)[O-])c1OCc1ccccc1
HCID69102620

未命名化合物

PRODUCTS

生成物

1
结构：C[C@H](O[Si](C)(C)C(C)(C)C)[C@@H](O)CCc1cccc(N)c1O
HCID69103771

未命名化合物

收率 99.4%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[Pd]
催化剂HCID23938

Palladium

Pd

结构：CCOC(C)=O
溶剂HCID8857

Ethyl acetate

C4H8O2

PROCEDURE

实验过程

A mixture of (3S,4S)-1-(2-benzyloxy-3-nitrophenyl)-4-(tert-butyldimethylsilyloxy)-1-penten-3-ol (P0015; 610 mg) and 10% Pd—C (120 mg) in EtOAc (6 ml) was stirred under hydrogen atmosphere at atmospheric pressure for 1 hour. Pd—C was removed by filtration through Celite. The filtrate was filtered through silica gel (6 g) and evaporated to give (3S,4S)-1-(3-amino-2-hydroxyphenyl)-4-(tert-butyldimethylsilyloxy)pentan-3-ol (P0016; 444.9 mg) as a brown solid.

WORKUP

后处理

  1. customPd—C was removed by filtration through Celite
  2. filtrationThe filtrate was filtered through silica gel (6 g)
  3. customevaporated