反应详情

温度

80 °C

The product from the previous step, 4-(1,2,3,4-Tetrahydro-acridin-9-yl)-phenol (22 mg, 0.08 mmol), 1-(3-Chloropropyl)-pyrrolidine (18 mg, 0.12 mmol), and K2CO3 (17 mg, 0.12 mmol) were mixed in NMP (267 uL) and stirred rapidly at 80° C. for 90 minutes in a sealed vial. The reaction mixture was cooled, partitioned between Et2O (50 mL) and H2O (10 mL). The organic layer was washed with H2O (3×10 mL), sat. aq. NaCl (10 mL), dried over Na2SO4, decanted and concentrated. The residue was purified using preparative LCMS to give product the desired product.

1. temperatureThe reaction mixture was cooled
2. custompartitioned between Et2O (50 mL) and H2O (10 mL)
3. washThe organic layer was washed with H2O (3×10 mL), sat. aq. NaCl (10 mL)
4. dry with materialdried over Na2SO4
5. customdecanted
6. concentrationconcentrated
7. customThe residue was purified